Associations between maternal plasma zinc concentrations in late pregnancy and LINE-1 and Alu methylation loci in the young adult offspring.

Amaraporn Rerkasem,Sothida Nantakool,Brooke C Wilson,Ampica Mangklabruks,Kongsak Boonyapranai,Apiwat Mutirangura,José G B Derraik,Kittipan Rerkasem

PloS one（2022）

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摘要

Lower maternal zinc concentrations late in gestation were associated with changes in DNA methylation in later life. Thus, zinc deficiency during pregnancy may induce alterations in total LINE-1 methylation and LINE-1 hypermethylation loci. These results suggest a possible epigenetic link between zinc deficiency during pregnancy and long-term outcomes in the offspring.

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maternal plasma zinc concentrations,alu methylation loci,late pregnancy

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