Plasma surface modification of two-component composite scaffolds consisting of 3D-printed and electrospun fiber components from biodegradable PLGA and PLCL

•3D printed / electrospun fibers porous scaffolds (3D/E) of PLCL and PLGA were designed and developed for tissue regenerative treatments.•The novel plasma-treated 3D/E scaffolds of PLCL and PLGA were successfully prepared using a nitrogen-argon plasma system (N2/Ar).•Treated 3D/E scaffolds lead to enhance hydrophilic properties and surface roughness, which was beneficial to enhance biological performance.•This study suggests a simple and fast way of printing and plasma technology to design, fabricate and modify scaffolds for tissue regenerative treatments.